Wissenschaftliche Tätigkeit

Hals-, Nasen- und Ohrenheilkunde

Die wissenschaftliche Tätigkeit und die Lehrtätigkeit an der Medizinischen Universität Wien machen mir ergänzend zu meiner ärztlichen Arbeit sehr viel Freude.

Mein Schwerpunkt im wissenschaftlichen Bereich sind Ursachen, Diagnose und Therapie von Riech- und Schmeckstörungen. Die fachliche Vernetzung – z.B. im Rahmen der AG Olfaktologie und Gustologie der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, wo ich Mitglied des erweiterten Vorstands bin – ermöglicht mir auch die Mitwirkung / Austausch bei internationalen Forschungsprojekten.

Mitwirkung an klinischen Studien

an der Med Uni Wien

2014	HNO-Klinik (Tavipec, Principal Investigator)
2009	HNO-Klinik (Carrageen-Nasenspray, Principal Investigator)
2007	Klinische Pharmakologie (nasale Grippeimpfung)
2006	HNO-Klinik (medikamentöse Tinnitustherapie)

Lehrtätigkeit

an der Medizinischen Universität Wien

HNO-Tertial Koordinator
Blockkoordinator Z2 (Oralpathologie und innere Organe)
Betreuung von Diplomarbeiten und Dissertationen
Abhaltung zahlreicher Lehrveranstaltungen (z.B. „Sicherung der Atemwege in der HNO-Heilkunde“)

Publikationen

Erst-/Letzt- und korrespondierende Autorenschaft

1) Mueller C, Temmel AF, Quint C, Rieger A, Hummel T. Olfactory function in HIV-positive subjects. Acta Otolaryngol 2002; 122(1):67-71.

2) Mueller C, Kallert S, Renner B, Stiassny K, Temmel AF, Hummel T, Kobal G. Quantitative assessment of gustatory function in a clinical context using impregnated „taste strips“. Rhinology 2003; 41(1):2-6.

3) Mueller C,Temmel AFP,Toth J, Quint C, Herneth A, Hummel T. CT scans in the evaluation of patients with olfactory dysfunction. Am J Rhinol 2006; 20(1):109-12.

4) Mueller C, Renner B. A new procedure for the short screening of olfactory function using five items from the “Sniffin`Sticks” identification test kit. Am J Rhinol 2006; 20(1):113-6.

5) Mueller CA, Grassinger E, Naka A, Temmel AFP, Hummel T, Kobal G. A self-administered odor identification test procedure using the “Sniffin`Sticks”. Chem Senses 2006; 31(6):595-8.

6) Mueller CA, Khatib S, Temmel AFP, Baumgartner WD, Hummel T. Effects of cochlear implantation on gustatory function. Ann Otol Rhinol Laryngol 2007; 116(7):498-501.

7) Mueller CA, Khatib S, Landis BN, Temmel AFP, Hummel T. Gustatory function after tonsillectomy. Arch Otolaryngol Head Neck Surg 2007; 133(7):668-671.

8) Müller CA, Reiter M, Renner B. Tipps&Tricks Diagnostik von Riech- und Schmeckstörungen in der klinischen Routine. Laryngo-Rhino-Otol 2007; 86(9):630-3.

9) Mueller CA, Quint C, Gulesserian T, Temmel AF, Hummel T. Olfactory function in children with cystic fibrosis. Acta Paediatr 2007;96(1):148-9.

10) Mueller CA, Khatib S, Naka A, Temmel AFP, Hummel T. Clinical assessment of gustatory function before and after middle ear surgery: A prospective study with a two-year follow up period. Ann Otol Rhinol Laryngol, 2008;117(10):769-73.

11) Mueller CA and Hummel T. Recovery of olfactory function after nine years of post-traumatic anosmia: a case report. J Med Case Reports 2009; Sep 16;3:9283.

12) Mueller CA, Pintscher K, Renner B. A clinical test of gustatory function including umami taste. Ann Otol Rhinol Laryngol, 2011;120(6):358-62.

13) Naka A, Riedl M, Luger A, Hummel T, Mueller CA. Clinical significance of smell and taste disorders in patients with diabetes mellitus. Eur Arch Otorhinolaryngol, 2010;267(4):547-50.

14) Ludwig M, Enzenhofer E, Schneider S, Rauch M, Bodenteich A, Neumann K, Prieschl-Grassauer E, Grassauer A, Lion T, Mueller CA. Efficacy of a carrageenan nasal spray in patients with common cold: a randomized controlled trial. Respir Res, 2013;14:124.

15) Naka A, Wolf A, Renner B, Mueller CA. A novel device for the clinical assessment of intranasal trigeminal sensitivity. Ann Otol Rhinol Laryngol, 2014;123(6):428-33.

16) Wolf A, Varga L, Wittibschlager L, Renner B, Mueller CA. A self-administered test of taste function using „Taste Strips“. Int Forum Allergy Rhinol, 2016;6(4):362-6.

17) Wolf A, Illini O, Uy D, Renner B, Mueller CA. A new extension to the Taste Strips test. Rhinology, 2016;54(1):45-50.

18) Wolf A, Renner B, Tomazic PV, Mueller CA. Gustatory Function in Patients with Chronic Rhinosinusitis. Annals Otol Rhinol Layngol, 2018;127(4):229-34.

19) Besser G, Liu DT, Renner B, Hummel T, Mueller CA. Olfactory implant: Demand for a future treatment option in patients with olfactory dysfunction. Laryngoscope, 2019; 129(2):312-316.

20) Besser G, Jobs L, Liu DT, Mueller CA, Renner B. The Sniffin‘ Sticks Odor Discrimination Memory Test: A Rapid, Easy-to-Use, Reusable Procedure for Testing Olfactory Memory. Ann Otol Rhinol Laryngol, 2019 Mar;128(3):227-232

21) Besser G, Prassl A, Mueller CA, Renner B. Testing gustatory function using either a forced-choice or a non-forced-choice paradigm – Does it make a difference? Rhinology, 2019 57(5):385-391.

22) Besser G, Liu DT, Renner B, Mueller CA. Self-administered Testing of Odor Threshold and Discrimination using Sniffin‘ Sticks – Reviving the „Odor-curves-on-paper“. Chem Percept, 2019. doi.org/10.1007/s12078-019-09263-x

23) Liu DT, Besser G, Renner B, Seyferth S, Hummel T, Mueller CA. Retronasal olfactory function in patients with smell loss but subjectively normal flavor perception. Laryngoscope, 2020 Jul;130(7):1629-1633.

24) Besser G, Erlacher B, Aydinkoc-Tuzcu K, Liu DT, Pablik E, Niebauer V, Koenighofer M, Renner B, Mueller CA. Body-Mass-Index Associated Differences in Ortho- and Retronasal Olfactory Function and the Individual Significance of Olfaction in Health and Disease. J Clin Med, 2020;9(2).

25) Liu DT, Besser G, Oeller F, Mueller CA, Renner B. Bitter Taste Perception of the Human Tongue Mediated by Quinine and Caffeine Impregnated Taste Strips. Ann Otol Rhinol Laryngol, 2020 Feb 6:3489420906187. doi: 10.1177/0003489420906187. [Epub ahead of print]

26) Liu DT, Besser G, Parzefall T, Riss D, Mueller CA. Winter peaks in web ‑ based public inquiry into epistaxis. Eur Arch Oto-Rhino-Laryngology, 2020;March 16.: https://doi.org/10.1007/s00405-020-05915-x .

27) Besser G, Liu DT, Renner B, Hummel T, Mueller CA. Reversible obstruction of the olfactory cleft: impact on olfactory perception and nasal patency. Int Forum Allergy Rhinol, 2020, in press.

28) Besser G, Oswald MM, Liu DT, Renner B, Mueller CA. Flavor Education and Training in Olfactory Dysfunction – a Pilot Study. Eur Arch Otorhinolaryngol. 2020, in press.

29) Besser G, Liu DT, Prem B, Iabloncsik D, Pablik E, Mueller CA, Renner B. Retronasal olfactory testing using candies sent by post and for screening purposes: a feasibility study. Rhinology. 2020, doi:10.4193/Rhin19.230.

30) Liu DT, Besser G, Oeller F, Mueller CA and Renner B. Bitter Taste Perception of the Human Tongue mediated by Quinine and Caffeine impregnated Taste Strips. Ann Otol Rhinol Laryngol, 2020 Accepted 23.1.2020. Impact factor: 1.458

31) Liu DT, Besser G, Lang M, Sharma G, Pablik E, Renner B, Mueller CA. Odor Mixtures in Identification Testing Using Sniffin’ Sticks: The SSomix Test. Sci Rep. 2020 Oct 22;10(1):18019. Impact factor: 4.011.

32) Liu DT, Besser G, Prem B, Sharma G, Koenighofer M, Renner B, Mueller CA. Association Between Olfactory Function and Subjective Chemosensory Perception in Patients with Olfactory Dysfunction. Laryngoscope. Accepted 11.05.2020. Impact factor: 2.343

33) Bernhard Prem, David Tianxiang Liu, Bernhard Parschalk, Boban M. Erovic & Christian A. Mueller (2020) Surgical management of severe facial trauma after dog bite: A case report, Acta Oto-Laryngologica Case Reports, 5:1, 17-22, DOI: 10.1080/23772484.2019.1708746

34) Liu DT, Besser G, Prem B, Speth MM, Besser G, Sedaghat AR, Mueller CA. Individual Importance of Olfaction Decreases with Duration of Smell Loss. Rhinology. 2020 Sep 14. doi: 10.4193/Rhin20.196. Online ahead of print. Impact factor: 3.01

35) Liu DT, Welge-Luessen A, Besser G, Mueller CA Renner B. Assessment of Odor Hedonic Perception: The Sniffin` Sticks Parosmia Test (SSParoT). Scientific reports, 2020 Impact factor: 3.99

36) Liu DT, Besser G, Prem B, Sharma G, Speth MM, Sedaghat AR, Mueller CA. Self-perceived Taste and Flavor Perception: Associations with Quality of Life in Patients with Olfactory Loss. Otolaryngology- Head and Neck Surgery, 2020. Impact factor: 2.341

37) Besser G, Liu DT, Sharma G, Bartosik TJ, Kaphle S, Enßlin M, Renner B, Mueller CA. Ortho- and retronasal olfactory performance in rhinosurgical procedures: a longitudinal comparative study. Eur Arch Otorhinolaryngol. 2021; 278(2):397-403.

38) Auinger AB, Besser G, Liu DT, Renner B, Mueller CA. Long-term impact of olfactory dysfunction on daily life. Wien Klin Wochenschr. 2020 Oct 21. doi: 10.1007/s00508-020-01751-5. Epub ahead of print. PMID: 33084955.

39) Schnoell J, Besser G, Jank BJ, Bartosik TJ, Parzefall T, Riss D, Mueller CA, Liu DT. The relationship between COVID-19 Cases and Deaths with Web-based Public Inquiries. Inf Diseases. 2020 doi: 10.1080/23744235.2020.1856406.

40) Liu DT, Schwarz-Nemec U, Renner B, Mueller CA, Besser G. Radiological Markers of the Olfactory Cleft: Relations to Unilateral Orthonasal and Retronasal Olfactory Function. Diagnostics. 2020 doi: 10.3390/diagnostics10110989.

41) Prem B, Mueller CA. Smell loss as initial symptom of olfactory groove meningioma. BMJ Case Rep 2021;0:e241013. doi:10.1136/bcr-2020-241013.

42) Prem B, Liu DT, Besser G, Renner B, Mueller CA. Retronasal olfactory testing in early diagnosed and suspected COVID-19 patients: a seven weeks follow-up study. Eur Arch Otorhinolaryngol. 2021 May 13:1–9. doi: 10.1007/s00405-021-06826-1. Epub ahead of print. PMID: 33987699.

43) Liu, D.T.; Besser, G.; Bayer, K.; Prem, B.; Mueller, C.A.; Renner, B. Bitter Taste Disrupts Spatial Discrimination of Piperine-Evoked Burning Sensations: A Pilot Study. Biology 2021, 10, 886. https://doi.org/10.3390/biology10090886

44) Müller, C.A., Renner, B. Riechstörungen evidenzbasiert diagnostizieren und behandeln. Der unterschätzte Sinn – neue Erkenntnisse belegen die Bedeutung und Leistungsfähigkeit des menschlichen Geruchssinns. Wien Med Wochenschr (2021). https://doi.org/10.1007/s10354-021-00895-x

45) Mueller CA, Winter M, Renner B. A Concept for the Reduction of Mucosal SARS-CoV-2 Load using Hypochloric Acid Solutions. Drug Res (Stuttg). 2021;71(6):348-350.

Ko-Autorenschaft

1) Kettenmann B, Mueller C, Wille C, Kobal G. Odor and taste interaction on brain responses in humans. Chem Senses 2005;30(Suppl 1):i234-i235.

2) Reden J, Mueller A, Mueller C, Konstantinidis I, Frasnelli J, Landis BN, Hummel T. Recovery of olfactory function following closed head injury or infections of the upper respiratory tract. Arch Otolaryngol Head Neck Surg. 2006;132(3):265-9.

3) Renner B, Clarke J, Grattan T, Beisel A, Mueller C, Werner U, Kobal G, Brune K. Caffeine accelerates absorption and enhances the analgesic effect of acetaminophen. J Clin Pharmacol, 2007; 47(6):715-26.

4) Loader B, Gruther W, Mueller CA, Neuwirth G, Thurner S, Ehrenberger K, Mittermaier C. Improved postural control after computerized optokinetic therapy based on stochastic visual stimulation in patients with vestibular dysfunction. J Vest Res, 2007;17:1-6.

5) Landis BN, Welge-Luessen A, Brämerson A, Bende M, Mueller CA, Nordin S, Hummel T. “Taste Strips” – A rapid, lateralized, gustatory bedside identification test based on impregnated filter papers. J Neurol, 2009; 256(2):242-8.

6) Renner B, Mueller CA, Dreier J, Faulhaber S, Rascher W, Kobal G. The Candy Smell Test: A new test for retronasal olfactory performance. Laryngoscope, 2009; 119:487-95.

7) Wacheck V, Egorov, A, Groiss F, Pfeiffer A, Fuereder T, Hoeflmayer T, Kundi M, Popow-Kraupp T, Redlberger-Fritz M, Mueller CA et al. A novel type of flu vaccine: safety and immunogenicity of replication-deficient influenza virus created by deletion of theinterferon antagonist NS1. J Infect Dis, 2010; 201:354-62.

8) Renner B, Mueller CA, Shephard A. Environmental and non-infectious factors in the aetiology of pharyngitis (sore throat). Inflamm Res, 2012; 61(10):1041-52.

9) Scheibe M, Schulze S, Mueller CA, Schuster B, Hummel T. Intranasal trigeminal sensitivity: measurements before and after nasal surgery. Eur Arch Otorhinolaryngol, 2014;271(1):87-92.

10) Koenighofer M, Lion T, Bodenteich A, Prieschl-Grassauer E, Grassauer A, Unger H, Mueller CA, Fazekas T. Carrageenan nasal spray in virus confirmed common cold: individual patient data analysis of two randomized controlled trials. Multidiscip Respir Med 2014, 9(1):57.

11) Kollndorfer K, Kowalczyk K, Hoche E, Mueller CA, Pollak M, Trattnig S, Schöpf V. Recovery of olfactory function induces neuroplasticity effects in patients with smell loss. Neural Plast. 2014;2014:140419. doi: 10.1155/2014/140419. Epub 2014 Dec 3.

12) Krajnik J, Kollndorfer K, Notter LA, Mueller CA, Schöpf V. The impact of olfactory dysfunction on interoceptive awareness. Psychophysiology. 2015;52(2):263-8.

13) Kollndorfer K, Kowalczyk K, Frasnelli J, Hoche E, Unger E, Mueller CA, Krajnik J, Trattnig S, Schöpf V. Same same but different. Different trigeminal chemoreceptors share the same central pathway. PLoS One. 2015;10(3):e0121091.

14) Kollndorfer K, Kowalczyk K, Nell S, Krajnik J, Mueller CA, Schöpf V. The inability to self-evaluate smell performance. How the vividness of mental images outweighs awareness of olfactory performance. Front Psychol 2015;6:627.

15) Kollndorfer K, Fischmeister FP, Kowalczyk K, Hoche E, Mueller CA, Trattnig S, Schöpf V. Olfactory training induces changes in regional functional connectivity in patients with long-term smell loss. Neuroimage Clin 2015;9:401-10.

16) Kollndorfer K, Jakab A, Mueller CA, Trattnig S, Schöpf V. Effects of chronic peripheral olfactory loss on functional brain networks. Neuroscience 2015;310:589-99.

17) Schöpf V, Kollndorfer K, Pollak M, Mueller CA, Freiherr J. Intranasal insulin influences the olfactory performance of patients with smell loss, dependent on the body mass index: A pilot study. Rhinology 2015;53:371-8.

18) Hummel T, Whitcroft KL, Andrews P, Altundag A, Cinghi C, Costanzo RM, Damm M, Frasnelli J, Gudziol H, Gupta N, Haehner A, Holbrook E, Hong SC, Hornung D, Hüttenbrink KB, Kamel R, Kobayashi M, Konstantinidis I, Landis BN, Leopold DA, Macchi A, Miwa T, Moesges R, Mullol J, Mueller CA, Ottaviano G, Passali GC, Philpott C, Pinto JM, Ramakrishnan VJ, Rombaux P, Roth Y, Schlosser RA, Shu B, Soler G, Stjärne P, Stuck BA, Vodicka J, Welge-Luessen A. Position paper on olfactory dysfunction. Rhinology 2016;56(1):1.30.

19) Walliczek-Dworschak U, Pellegrino R, Taube F, Mueller CA, Stuck BA, Dworschak P, Güldner C, Steinbach S. Chemosensory function before and after multimodal treatment in chronic rhinosinusitis patients. Laryngoscope 2018;128(3):E86-E90.

20) Eva E. Waltl, Regina Selb, Julia Eckl-Dorna, Christian A. Mueller, Clarissa R. Cabauatan, Thomas Eiwegger, Yvonne Resch-Marat, Katarzyna Niespodziana, Susanne Vrtala, Rudolf Valenta, Verena Niederberger. Betamethasone prevents human rhinovirus- and cigarette smoke- induced loss of respiratory epithelial barrier function. Sci Rep. 2018; 8: 9688. Published online 2018 Jun 26. doi: 10.1038/s41598-018-27022-y

21) Eva E. Waltl, Victoria Stanek, Christian A. Mueller, Renata Kiss, Julia Eckl-Dorna, Rudolf Valenta, Verena Niederberger. Primary Nasal Epithelial Cells From Allergic and Non-allergic Individuals Show Comparable Barrier Function. Allergy Asthma Immunol Res. 2020 Mar; 12(2): 364–370. Published online 2019 Dec 20. doi: 10.4168/aair.2020.12.2.364

22) Damm M, Schmitl L, Müller CA, Welge-Lüssen A, Hummel T. Diagnostik und Therapie von Riechstörungen. HNO. 2019 Apr;67(4):274-281.

23) Schneider, S.; Campion, N.J.; Villazala-Merino, S.; Liu, D.T.; Bartosik, T.; Landegger, L.D.; Ahmadi, N.; Mueller, C.A.; Vyskocil, E.; Stanek, V.; Quint, T.; Bangert, C.; Eckl-Dorna, J. Associations between the Quality of Life and Nasal Polyp Size in Patients Suffering from Chronic Rhinosinusitis without Nasal Polyps, with Nasal Polyps or Aspirin-Exacerbated Respiratory Disease. J. Clin. Med. 2020, 9, 925. Impact factor: 5.688

24) Bartosik TJ, Liu DT, Campion NJ, Villazala-Merino S, Janik S, Dahm V, Mueller CA, Vyskocil E, Stanek V, Quint T, Bangert C, Eckl-Dorna J, Schneider S. Differences in men and women suffering from CRSwNP and AERD in quality of life. Eur Arch Otorhinolaryngol. 2020 Oct 15. doi: 10.1007/s00405-020-06418-5. Epub ahead of print. PMID: 33063145.

25) Zou L, Hummel T, Otte MS, Bitter T, Besser G, Mueller CA , Welge-Lüssen A, Bulut OC, Göktas Ö, Negoias S, Li S , Haehner A (2020) Association between olfactory function and quality of life in patients with olfactory disorders: a multicenter study in over 760 participants. Rhinology. 2020 (in press).

Reviewer-Tätigkeit

für folgende Journale

Rhinology
European Archives of Oto-Rhino-Laryngology
Journal of Clinical Medicine
Scientific Reports
Chemical Senses

Mitgliedschaften

bestens vernetzt

Österreichische Gesellschaft für Hals-, Nasen- und Ohrenheilkunde, Kopf- und Halschirurgie
Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie (Mitglied des erweiterten Vorstandes der AG Olfaktologie/Gustologie)
European Rhinologic Society
Association for Chemoreception Sciences

mehr über mich

Wissenschaftliche Tätigkeit

WISSENSCHAFT

Mitwirkung an klinischen Studien

Lehrtätigkeit

Publikationen

Erst-/Letzt- und korrespondierende Autorenschaft

Ko-Autorenschaft

Reviewer-Tätigkeit

Mitgliedschaften

Dr. Christian A. Müller

HNO Wahlarzt Ordination

HNO-Universitätsklinik

Wissen­schaft­liche Tätigkeit

WISSENSCHAFT

Mitwirkung an klinischen Studien

Lehrtätigkeit

Publikationen

Erst-/Letzt- und korrespondierende Autorenschaft

Ko-Autorenschaft

Reviewer-Tätigkeit

Mitgliedschaften

Dr. Christian A. Müller

HNO Wahlarzt Ordination

HNO-Universitäts­klinik

Wissenschaftliche Tätigkeit

HNO-Universitätsklinik